Forschung und Entwicklung

Scantamburlo G, Nofziger C, Paulmichl M, Vanoni S. Genetic analysis of the equine orthologues for human CYP2D6: unraveling the complexity of the CYP2D family in horses. Front. Vet. Sci. 2023;10:1188633. doi:10.3389/fvets.2023.1188633

Turner A.J., Nofziger C., Ramey B.E., Ly R.C., Bousman C.A., Agúndez J.A.G., Sangkuhl K., Whirl-Carrillo M., Vanoni S., Dunnenberger H.M., Ruaño G., Kennedy M.A., Phillips M.S., Hachad H., Klein T.E., Moyer A.M., Gaedigk A, PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting. Clin. Pharmacol. Ther. 2023. doi: 10.1002/cpt.3044

Marella S., Sharma A., Ganesan V., Ferrer-Torres D., Krempski J.W., Idelman G., Clark S., Nasiri Z., Vanoni S., Zeng C., Dlugosz A.A., Zhou H., Wang S., Doyle A.D., Wright B.L., Spence J.R., Chehade M., Hogan S.P., IL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis. J. Allergy Clin. Immunol. 2023. doi: 10.1016/j.jaci.2023.07.021

Wang W.Y., Twesigomwe D, Nofziger C, Turner AJ, Helmecke LS, Broeckel U, Derezinski AD, Hazelhurst S, Gaedigk A, Characterization of Novel CYP2D6 Alleles across Sub-Saharan African Populations. J.Pers. Med. 2022, 12, 1575. doi.org/10.3390/jpm12101575

Vanoni S, Matulevicius A, Avdiu B, Scantamburlo G, Ulekleiv C, Brzoska PM, Furtado MR, Feenstra JDM, Rico A, Gandhi M, Giacobazzi E, Masi E, Paulmichl M and Nofziger C SARS-CoV-2 variants of concern surveillance including Omicron using RT-PCR– based genotyping offers comparable performance to whole genome sequencing. Front. Cell. Infect. Microbiol. 12:960065. doi: 10.3389/fcimb.2022.960065

Uddin J, Tomar S, Sharma A, Waggoner L, Ganesan V, Marella S, Yang Y, Noah T, Vanoni S, Patterson A, Zeng C, Foster PS, Newberry R, Bishu S, Kao JY, Rosen MJ, Denson L, King P, Hoebe K, Divanovic S, Munitz A, Hogan SP. „PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses“. Cell Mol Gastroenterol Hepatol. 2021 Jul 6:S2352-345X(21)00128-4. doi: 10.1016/j.jcmgh.2021.06.013.

Noah TK, Knoop KA, McDonald KG, Gustafsson JK, Waggoner L, Vanoni S, Batie M, Arora K, Naren A, Wang YH, Lukacs NW, Munitz A, Helmrath M, Mahe MM, Newberry R, Hogan SP. „IL-13-induced intestinal secretory epithelial cell antigen passages are required for IgE-mediated-food-induced anaphylaxis.“ J Allergy Clin Immunol. 144(4):1058-1073, 2019

Vanoni S, Scantamburlo G, Dossena S, Paulmichl M and Nofziger C. Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia. International Journal of Molecular Sciences. 20(3):731, 2019.

Vanoni S, Zeng C, Marella S, Uddin J, Wu D, Arora K, Ptaschinski C, Que J, Noah T, Waggoner L, Barski A, Kartashov A, Rochman M, Wen T, Martin L, Spence J, Collins M, Mukkada V, Putnam P, Naren A, Chehade M, Rothenberg ME, Hogan SP. „Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis” J Allergy Clin Immunol. 2020 Jan;145(1):239-254.e2.doi: 10.1016/j.jaci.2019.07.049. Epub 2019 Oct 21.

Wheeler JC, Vanoni S, Zeng C, Waggoner L, Yang Y, Wu D, Uddin J, Karns R, Kottyan L, Mukkada V, Rothenberg ME and Hogan SP. „17b-Estradiol protects the esophageal epithelium from IL-13-induced barrier dysfunction and remodeling“. J Allergy Clin Immunol. 143(6):2131-2146, 2019.

Zeng C, Vanoni S, Wu D, Caldwell JM, Wheeler JC, Arora K, Noah TK, Waggoner L, Besse JA, Yamani AN, Uddin J, Rochman M, Wen T, Chehade M, Collins MG, Mukkada VA, Putnam PE, Naren AP, Rothenberg ME and Hogan SP. Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis. J Allergy Clin Immunol. In Press, 2018.

Costa R, Civello DA, Bernardinelli E, Vanoni S, Zopf M, Scantamburlo G, Nofziger C, Patsch W, Paulmichl M and Dossena S. A Potassium-Selective Current Affected by Micromolar Concentrations of Anion Transport Inhibitors. Cell Physiol Biochem 45:867-882, 2018.

Scantamburlo G, Tziolia K, Zopf M, Bernardinelli E, Soyal SM, Civello DA, Vanoni S, Dossena S, Patsch W, Patrinos GP, Paulmichl M and Nofziger C. Allele drop-out conferred by a frequent CYP2D6 genetic variation for commonly used CYP2D6*3 Genotyping Assays. Cell Physiol Biochem 43:2297-2309,

Wang N, McKell M, Dang A, Yamani A, Waggoner L, Vanoni S, Noah T, Wu D, Kordowski A, Köhl J, Hoebe K, Devanovic S and Hogam SP. Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Clin Exp Allergy 47:1574-1585, 2017.

Bernardinelli E, Costa R, Scantamburlo G, To J, Morabito R, Nofziger C, Doerrier C, Krumschnabel G, Paulmichl M and Dossena S. Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death. PLOS ONE 19:e0179591, 2017.